After reanalyzing results from 17 previously published clinical trials, researchers are, once again, entertaining the possibility that isoflavones in soy may have weak estrogen-like effects in some body tissue after discovering that women who used soy isoflavone extracts had a 21% greater reduction in hot flashes compared with women given a placebo. Women who were using soy extracts also experienced hot flashes that tended to be “less severe.”
The findings, reported online March 19th in Menopause, add to a generally conflicting body of research on what works for hot flashes.
The one consistently supported treatment for hot flashes is hormone replacement therapy (HRT), which is also linked to increased risks of blood clots, heart attack, stroke and breast cancer. Alternatives to HRT include certain antidepressants and blood pressure medications, and the anti-seizure drug gabapentin. But the evidence on those drugs is also mixed, and none is approved for hot flashes.
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Source: Reuters Health