Inflammation from Celiac Disease May Lead to Heart Problems

People who have celiac disease may face double the risk of coronary artery disease compared with the general population, according to new research.

The study, the first to examine the association between celiac disease and coronary artery disease, adds to the evolving understanding of how systemic inflammation and autoimmune processes might influence how cardiovascular disease develops. The study also found that people with celiac disease have a slightly higher risk of stroke.

Celiac disease is a chronic inflammatory condition of the digestive system. Left untreated, it can damage the small intestine, eventually interfering with the absorption of key nutrients. People with celiac disease are unable to tolerate gluten – a protein found in food such as wheat, rye and barley. Gluten is thought to trigger an immune and inflammatory response in the gut.

“People with celiac disease have some persistent low-grade inflammation in the gut that can spill immune mediators into the bloodstream, which can then accelerate the process of atherosclerosis and, in turn, coronary artery disease,” said Dr. R.D. Gajulapalli, clinical associate at the Cleveland Clinic and co-investigator of the study. “Our findings reinforce the idea that chronic inflammation, whether it’s from an infection or a disease, can have an adverse role in coronary artery disease and heart health in general.”

The study was presented at the annual scientific meeting of the American College of Cardiology.

Researchers used the electronic health records of patients from 13 participating health care systems between January 1999 and September 2013. Out of a total of nearly 22.4 million patients, 24,530 were diagnosed with celiac disease.

Researchers found a significantly higher prevalence of coronary artery disease among patients with celiac disease compared to the control population (9.5 percent compared to 5.6 percent, respectively), according to the news release from the American College of Cardiology. Data showed a similar trend among younger patients, those under age 65, with celiac disease compared to those without celiac disease (4.5 percent compared to 2.4 percent).

“This is an important study because it highlights a specific patient population who might be at higher risk for coronary artery disease, even in the absence of traditional cardiovascular risk factors,” Gajulapalli said. “We were surprised by the strength of the association, especially in younger people. Patients and doctors should be aware of this association.”

Celiac disease affects an estimated 1 in 133 Americans. But experts believe upwards of 80 percent of people with celiac disease are underdiagnosed or misdiagnosed with conditions such as lactose intolerance and irritable bowel syndrome.

The only treatment for celiac disease is adopting a gluten-free diet. Although gluten is mainly found in foods, it can also be in medicines, vitamins and lip balms.

Celiac disease has been linked to arrhythmias (problems with the heart’s rhythm) and possible heart failure.

“Whether patients with celiac disease will need more intense risk factor modification like in diabetic patients with coronary artery disease will need to be studied,” Gajulapalli said. For now, he says people with this and other inflammatory diseases should maintain a healthy lifestyle and be aware of traditional cardiovascular risk factors including diabetes, high blood pressure and high cholesterol, the news release states.

Larger studies are needed to confirm this association and to examine how the severity of celiac disease may play a role.

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